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Accordingly, several cellular hallmarks of proteotoxic stress have been identified, including dysregulated mTOR signaling and autophagy, compartment-specific unfolded protein response in mitochondria (UPR mt ), and in the endoplasmic reticulum (UPR ER )

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10.1038/s41598-021-81816-1 3 BanoS.HasnainM.RehmanK.KanwalT.PerveenS.YasmeenS.et al (2023)

Mice were then transferred to a 6 C cold chamber at 10 weeks of age

Moreover, in facing various pathological challenges, the mammalian heart, which possesses high levels of mitochondria and weak antioxidant capacity, is susceptible to oxidant production and oxidative damage