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They advocate for a treatment approach that is: Symptom-led : Recognising that many patients become symptomatic well before their next scheduled dose, meaning they are being under-treated

Vitamin B12 levels annually or if neurological symptoms develop

(2016) 150:130518.e8

10.1016/j.lfs.2019.117152 8

(Royal Society of Chemistry)Cancer-targeted drug delivery systems with permeability of the blood-brain barrier (BBB) have become of great interest for the rational design of high-efficiency anticancer agents
