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While heterologous desensitization of the 2 AR was mediated primarily by PKA, a novel catecholamine-activated cAMP-independent kinase, termed AR kinase (ARK, later named GRK2), was responsible for the process of homologous desensitization [11, 12]

The peak functionality of iHLOs at Day 30, evidenced by maximal expression of CYP450 enzymes like CYP3A4, CYP2B6, and CYP2C9, revealed optimal conditions for xenobiotic metabolism studies

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Lancet 1991;338:131-7 American Academy of Pediatrics (AAP) Committee on Drugs