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TrxR, thioredoxin reductase Graphical abstract Highlights Thiol-mediated signalling is a central node in the cellular redox network

The monothiol isoenzyme Grx3 is a multidomain protein that is present in the nucleus as well as in the cytoplasm, while the monothiol Grx5 is found in mitochondria [152]

How IV Glutathione Differs from Oral Supplements Absorption Matters Oral supplements pass through the digestive system, where much of the glutathione is broken down before absorption

For instance, the use of erastin can reduce the efflux of the multidrug resistance protein ATP-binding cassette subfamily B member 1 (ABCB1), leading to increased accumulation of chemotherapeutic drugs within tumor cells, thereby reversing resistance to docetaxel and platinum-based drugs (Zhou et al., 2019)

Finally, targeted modulation of NFB and STAT3 pathways may offer selective protection against neuro-inflammation in dementia, for example using natural and rationally-designed inhibitors of the NFB pathway (as reviewed, Srinivasan and Lahiri, 2015) and small molecule STAT3 inhibitors which are effective in cancer models (Fletcher et al., 2011)