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The three-region rotation system: Region 1: Abdomen (at least 2 inches from the navel, alternating left and right sides) Region 2: Front or outer thigh (middle third, alternating left and right legs) Region 3: Upper arm (back of the arm, alternating sides, may need assistance) Weekly rotation pattern: Week 1: Left abdomen Week 2: Right thigh Week 3: Right abdomen Week 4: Left thigh Week 5: Left abdomen (different spot from Week 1) Within each region, maintain at least 1 inch between consecutive injection sites