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Additional factors that may contribute to arm pain include: What Causes Injection Site Reactions After a Flu Shot

The methodologic design of the rescue arm favors the sq methotrexate group, in that, on average, approximately 10% of the subjects in this group received a 25% higher dose of methotrexate than did those in the oral group (who could never receive a dose higher than 15 mg as part of the protocol)

Pharma 47, 681688

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