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Bill Skarsgrd on playing Pennywise, the nightmarish clown of Stephen King's blockbuster 'It': "They were times that I felt I was going insane."

Although overall TMAO production did not change between the dietary fiber and placebo group (p-value=0.26, 95% CI), subgroup analysis revealed that fiber supplementation attenuated TMAO formation following beef intake in participants with lower habitual meat consumption (<3 times/week, p-value=0.029, 95% CI)

Trial registration ChiCTR-TNRC-12002835 .

Our findings suggest that GSK-3 plays an important role in astrocytic differentiation of human glioblastoma cells and may be a novel therapeutic target in the malignant tumor.

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