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This was further supported by additional studies showing elevated autoantibody levels against EBV nuclear and membrane structures, as well as autoantibodies against neurotransmitters and their receptors [95], increased IgM response against high levels of oxygen reactive species (ROS) and nitric oxide (NO), or the highly reactive oxidant peroxynitrite, respectively [93]

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Depression, also called major depressive disorder or clinical depression, is the most prevalent mood disorder in the United States and the world, affecting 8-10 percent of the general population at any given time, with every fourth person likely to experience the condition over the course of a lifetime