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This study also revealed lower levels of glutathione in the anterior cingulate cortex (ACC) and thalamus, which supports the idea of origin of glutamate from glutathione (16)

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The compound distributes preferentially to metabolically active organs, showing highest concentrations in the kidneys and liver, followed by the stomach wall, thymus, spleen, and intestines

Risk factors include the speed and magnitude of weight loss, pre-existing nutritional deficiencies, age, sex (women are more commonly affected), and individual genetic susceptibility