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The potential for probiotics to inadvertently concentrate MPs in specific gut regions or to alter their distribution and retention remains underexplored and warrants further investigation [63]

4 Molecular mechanisms of the activation of pro-inflammatory response caused by bacterial invasion Dysbacteriosis of the gut microbiota can lead to disruption of intestinal barrier function and immune homeostasis

Table 1 summarises different approaches to target the IGF-1R

and decreased the expression of caspase-3, inhibited apoptosis, and ultimately attenuated cisplatin-induced hair cell loss in the HEI-OC1 cell line (Choi et al., 2014)

melanogaster has been proposed to enhance autophagy and cardiac health through increasing the expression of Rictor, while depleting Rictor blunted this effect (Chang et al., 2020)