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Mitochondrial dysfunction in glaucomatous degeneration

These compounds act through modulation of neuroinflammation and oxidative stress by regulating microglial activation and reducing proinflammatory cytokines (Veselinovi et al., 2021)

Neuro Endocrinol Lett 32(2):133140 Maes M, Fiar Z, Medina M et al (2012) New drug targets in depression: inflammatory, cell-mediated immune, oxidative and nitrosative stress, mitochondrial, antioxidant, and neuroprogressive pathways

members of the NADPH oxidase (NOX) family, the mitochondrial electron transport chain, or extracellular lysyl oxidase activity in collagen crosslinking 19,20,21,22
Conversely, alternatively activated M2 macrophages rely predominantly on oxidative phosphorylation (OXPHOS), fatty-acid -oxidation (FAO), and an intact TCA cycle
