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Antiviral antibody activities in vivo The antiviral activities of nAbs as assessed by in vitro assays may operate in vivo but it is difficult to determine the relative contributions of the different mechanisms direct neutralization, nAb-mediated effector functions against free virions or infected cells, or virus sequestration
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However, this was blocked if the AP-1 and NFB binding sites were mutated, proving the importance of these cis -acting elements at least in the rat GCLC
