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Unlike cancer cells, CD4 + T cells or Treg cells, CD8 + T cells are unable to adapt to lipid-rich TMEs by shifting their metabolism from glycolysis to oxidative phosphorylation, and the accumulated lipids produce high levels of oxidative stress that ultimately inhibits cytotoxic functions [340]

[DOI] [PubMed] [Google Scholar] 34.Bodaghi-Namileh V., Sepand M.R., Omidi A., Aghsami M., Seyednejad S.A., Kasirzadeh S., Sabzevari O

Papadakis G, Kandaraki EA, Tseniklidi E, Papalou O, Diamanti-Kandarakis E

Future studies are required to evaluate how host immune responses are modulated by complex polymicrobial biofilms commonly found in wound beds and to better understand if these processes are affected by the wound type/tissue microenvironment