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However, the efficacy of glutamine inhibitors in selectively targeting certain tumors while concurrently impeding the immune response of the host organism is a salient concern

10.1016/j.tem.2021.07.006 Trends Endocrinol Metab

F16 targets the mitochondrial stroma and induces mPTP opening, and its conjugates enhance cytotoxicity and aid tumor imaging, but are toxic to normal cells

coli , regulating the intracellular metabolic state towards an antioxidant stress response to counteract the bactericidal effect caused by antibiotic-induced ROS

Accurate redox regulation is necessary for cellular signaling because reactive oxygen and nitrogen species (ROS and RNS) participate in numerous signaling pathways [127, 128]