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CAY10603 significantly inhibits the activation of the NLRP3 inflammasome in the STZ-induced DKD mice model, HK-2 cells stimulated by TGF-, and ATP/nigericin-induced iBMDM inflammation model by inhibiting the expression of HDAC6 to reduce the infiltration of macrophages and improve the renal tubule injury and interstitial fibrosis

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