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doi: 10.1016/0024-3205(85)90238-3

doi: 10.3892/ol.2018.8247 84 PriceDLLinSHanZSimpsonGCoffinRSWongJet al

This modification results in a significantly longer half-life, much lower affinity for the IGFBPs and, consequently, around a 3-fold increase in potency [95]

(2) Preparation of the intermediate ( S )-3 : a) Preparation of a chiral catalyst: Dichloro (4-methyl isopropyl benzene) ruthenium (II) dimer (0.006 mmol, 3.7 mg), and a chiral ligand ( S, S )-CsDPEN (0.013 mmol, 5.6 mg) were placed in a 25 mLreaction flask, into which was added water (0.6 mL) and stirred at 40C under nitrogen protection for 4 h to prepare the catalyst, ready for use

IKEMA and CANDOR Results from a phase Ib study (NCT02332850) indicated that isatuximab combined with carfilzomib was clinically active in heavily pretreated RRMM patients [72]