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This process drives dysregulation of macrophage polarization and excessive production of pro-inflammatory cytokines and induces synovial fibroblast proliferation and activation

Peptides are small fragments of proteins, chains of two or more amino acids that are linked together by ribosomes during the process of protein synthesis
One study, which also evaluated cognitive function in patients with high MMA concentrations, found no significant effects on the MDD inventory score, but only 30 of the 140 subjects had depression at baseline, which may have diluted any benefits
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