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The abdomen may fill with fluid and fluid may also leak from veins in the limbs, causing swelling, known asperipheral oedema.Left-sided congestive heart failure(LS-CHF) is when the heart pumps, instead of the left ventricle pushing the blood into the systemic circulation, some blood leaks through the mitral valve back into the left atrium and then it backs up into the lungs

The metabolism is raised due to the demand for this vitamin

Moderately and severely affected patients have mutations that compromise the catalytic properties of the enzyme