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AGEs, Advanced glycation endproduct

Effects of ketogenic diet on cognitive function in pentylenetetrazol-kindled rats

The Journal of Cell Biology, 100 (3), 904915

Evidence show berberine recovers DSS-induced UC in a microbial-dependent manner, with it maintaining the structure and function of the intestinal mucosal barrier, regulating intestinal mucosal immune homeostasis, activating Wnt/-catenin pathway, 521 FXR/TGR5 signaling, increasing unconjugated bile acids and secondary bile acids in the gastrointestinal tract, 522 activating aromatic hydrocarbon receptors 523 to exert its protective effect in the colon

Similarly, Mingmu Decoction reduced proinflammatory gene levels within the TNF- regulatory network (96), whereas Danggui Buxue Decoction significantly decreased retinal TNF- expression in GK rats, mitigating high-glucose-induced endothelial cell migration and proliferation (97)