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PDHA1 in RA FLS may be in an inhibited state, thus contributing to the excessive glycolytic and hyperproliferative state of FLS

parental involvement

Such imbalances impede the bone remodeling process and promote vascular calcification (VC), which significantly impacts patients with stage 5 CKD ( Chronic kidney disease-mineral and bone disorder exhibits a complex interplay with the immune system, driven by chronic inflammation and gut dysbiosis, which significantly influence mineral metabolism and cardiovascular outcomes in CKD patients

Initial research has shown early promise in for its regenerative and anti-inflammatory effects