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This drives more chondrocytes into oxidative damage and ferroptosis, thereby exacerbating the overall pathological progression of OA (Morquette et al., 2006)

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Our subsequent studies in human endothelial cells showed that the homocysteine metabolite, S-adenosylhomocysteine, a potent inhibitor of many methyltransferases, decreased tRNA Sec methylation to suppress GPx1 expression and activity [69]

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Moreover, results are shown after the first session

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