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Sci Rep (2019) 9:12978

593,599 Additionally, supplementation with NMN restores the activity of kidney SIRT1, thereby reducing the stress response by regulating the JNK pathway and protecting mice from cisplatin-induced AKI

& Long, G

& Mackman, N

So, if for example you experience worse fatigue after B12 injections, it might be a brief phase where your body is still using the unhealthy red blood cells
