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Description
It performs best as an adjunct, not a replacement

Test before you start and again at 46 weeks

In the SURMOUNT-1 trial with 2,539 adults with obesity, participants on the highest tirzepatide dose (15 mg weekly) lost an average of 20.9% of their body weight over 72 weeks

Dynamic interactions of ABHD5 with PNPLA3 regulate triacylglycerol metabolism in brown adipocytes

However, urine microscopy was negative for red blood cells and the chromaturia was due to hydroxocobalamin administration
