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The permeability transition pore complex: another view
R023 mainly interacts through its variable light (L) chain domain (V L ) with the HLA, while its variable heavy (H) chain domain (V H ) is mostly involved in hapten recognition 33

Effect of Gly-Gly-His, Gly-His-Lys and their copper complexes on TNF-alpha-dependent IL-6 secretion in normal human dermal fibroblasts

It is a popular term for higher intestinal permeability, meaning the barrier is more open than it should be

For instance, 4-hydroxynonenal treatment reduces tight junction protein expression in the colon, boosts bacterial movement from the gut to circulation, and intensifies Toll-like receptor-4 signaling activation (37)