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However, not all studies have reached similar conclusions

This needs to be verified, though, in carefully planned, more prolonged studies

PMID 14581383

Interventions that prevent protein misfolding and aggregation could increase both healthspan and lifespan

However, GSH-S-transferase A4-4 knockdown could augment 4-HNE cytotoxicity, and its overexpression could obviously inhibit 4-HNE-induced death of chondrocytes [84]
