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Specifically, we want to understand 1) what specifies cell identity and 2) how a cell can change its fate or state in response to intrinsic and extrinsic cues

Also, in many variants of these SPAAC and IEDDA, reaction mixtures of regioisomers are formed (unlike the CuAAC, which is highly 1,4-selective) and in some cases bulky linkages may prevent effective syntheses of functional structures (as opposed to those that have simply been labelled) such as PTM mimics, which can often be quite small and structurally subtle

Similarly, microscopic studies of PMN infections by the obligate intracellular pathogen Anaplasma phagocytophilum have shown that this bacterium prevents the assembly of cytb 558 at the phagosomal membrane

HLA-matched unrelated donor and HLA-matched related donor HSCT are associated with similar event-free survival but HLA-matched unrelated donor HSCT may increase risk of acute and chronic GVHD in patients with -TM (180)