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1 Introduction Melanoma represents the most aggressive and lethal form of skin cancer, characterized by its rapid progression, high metastatic potential, and notable resistance to conventional therapies ( A hallmark of melanoma malignancy is its ability to evade programmed cell death, which contributes to tumor progression and therapeutic resistance ( Ferroptosis, an iron-dependent form of regulated cell death characterized by the accumulation of lipid peroxides and reactive oxygen species (ROS), has emerged as a particularly promising target in melanoma therapy ( In addition to ferroptosis, other non-apoptotic RCD pathways such as pyroptosis and necroptosis have gained attention for their roles in melanoma biology and therapy (30)
Liu Y, Dong W, Ma Y, et al

"Induced overexpression of mitochondrial Mn-superoxide dismutase extends the life span of adult Drosophila melanogaster"

Glutatyonun balca ilevleri unlardr: Detoksifikasyon : Karacierin toksinleri etkili bir ekilde atmasna yardmc olur

Liquid biopsy is a non-invasive method that enables dynamic monitoring of circulating tumor DNA (ctDNA), providing insights into tumor heterogeneity and genomic alterations across different sites, including the primary tumor and off-target metastatic lesions
