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1 Introduction Melanoma represents the most aggressive and lethal form of skin cancer, characterized by its rapid progression, high metastatic potential, and notable resistance to conventional therapies ( A hallmark of melanoma malignancy is its ability to evade programmed cell death, which contributes to tumor progression and therapeutic resistance ( Ferroptosis, an iron-dependent form of regulated cell death characterized by the accumulation of lipid peroxides and reactive oxygen species (ROS), has emerged as a particularly promising target in melanoma therapy ( In addition to ferroptosis, other non-apoptotic RCD pathways such as pyroptosis and necroptosis have gained attention for their roles in melanoma biology and therapy (30)

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Liu Y, Dong W, Ma Y, et al

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"Induced overexpression of mitochondrial Mn-superoxide dismutase extends the life span of adult Drosophila melanogaster"

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Glutatyonun balca ilevleri unlardr: Detoksifikasyon : Karacierin toksinleri etkili bir ekilde atmasna yardmc olur

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Liquid biopsy is a non-invasive method that enables dynamic monitoring of circulating tumor DNA (ctDNA), providing insights into tumor heterogeneity and genomic alterations across different sites, including the primary tumor and off-target metastatic lesions

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