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Side effects typically return briefly with each dose increase but become less intense and shorter in duration with each subsequent escalation

Biological therapies, especially anti-TNF therapy are effective treatments, but the primary lack of response to TNF inhibitors or the secondary loss of response among some patients requires the search for new therapeutic solutions [121,122,123]

Western blot analysis of MARS1 and senescence markers (LAMINB1, p53, p21, p16) in HCMECs with MARS1 knockdown (P10-15) (I) or MARS1 overexpression (P3-P8) (J) treated with 200 M Hcy for 96h

[DOI] [PubMed] [Google Scholar] 115.Liu L, Hausladen A, Zeng M, Que L, Heitman J, Stamler JS

Critically, this sensitization is sustained by a selfreinforcing neuroimmuneglial axis
