l-carnitine fatty acid transport into mitochondria role Carnitine: Genetic Variants Affecting Mitochondrial Energy and Health The carnitine system and cancer

1.2 Biochemical mechanisms of TMA production Most of the TMA is synthesized in the intestine (colon) by the action of some anaerobic commensal gut bacteria containing choline- (or carnitine-) TMA lyase, an enzyme consisting of two units: a catalytic unit (CutC) and its activating enzyme (CutD) ( etc .), betaine, and L-carnitine and its metabolite -butyrobetaine (GBB), releasing TMA after the cleavage of the carbon (C)nitrogen (N) bond of choline/carnitine (Zhu et al., 2014)

10.3389/fphar.2022.917329 48 LiQ.TanJ

Si cette tude a t effectue sur 24 semaines, les effets de la carnitine se feront sentir aprs 6 mois de faon significative

doi: 10.3233/NUA-150051

10.1093/schbul/sbn121 Schizophr