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In addition, SLC7A11, the antiporter providing intracellular cystine (necessary to maintain intracellular GSH levels) also increased (Figure 2C and Supplemental Figure 2A)

Some of the primary genes impacted are COL1A1 (matrix), VEGFA (angiogenesis), IL6 (inflammation), and SOD2 (oxidative defense)

G., Testa R., Savarino V

In both cases, bound-form glutathione must be converted to reduced-form glutathione or cysteine on or in the hepatocytes

Medical News Today, 2024
