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Several studies failed to prove the positive effects of carnitine supplementation on hemoglobin levels (Table 3)

Studies in Crat knockout mice demonstrated that CrAT deficiency leads to abnormal fuel selection, which results in a perturbation of glucose homeostasis and suggest that deficits in CrAT activity might contribute to diet-induced metabolic inflexibility by exacerbating the Randle glucose-fatty acid cycle 66

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Carnitine can also play an important role in the prevention of certain illnesses , and its intake has been associated with a reduction in the risk of developing certain cardiovascular diseases, such as hypertension, heart attack and stroke, due to its ability to improve vascular health and reduce blood cholesterol levels, and it also plays a protective role against the development of certain neurodegenerative diseases, such as Alzheimer's and Parkinson's, due to its ability to protect nerve cells from oxidative stress

See below for specific information about nutrients and dietary factors relevant to coronary heart disease
