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Nuclei were counterstained with DAPI and mounted for imaging

This discrepancy is expected, and reported events could be because the pharmacokinetics of intravenous methylene blue are different than that of oral methylene blue

Side effects can generally be avoided by slowing down the rate of infusion and typically get better shortly after treatment

This interaction might involve the peptide acting as a histone mimic, facilitating changes in chromatin dynamics

The authors are also grateful to Sarawak Biodiversity Centre (SBC), Sarawak, Malaysia for the approval of research permit (SBC-2018-RDP-15-SZR), Faculty of Medicine and Health Sciences (FMHS), UNIMAS, Sarawak, Malaysia, Kulliyyah of Pharmacy, IIUM Kuantan Campus, Pahang, Malaysia and Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Selangor, Malaysia for the administrative and technical support