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Key persisting challenges include the absence of universally accepted definitions for functional respirasome configurations, incomplete understanding of stoichiometric prerequisites enabling efficient electron flux, and insufficient mechanistic insights into inter-complex crosslinking modalities that stabilize these macromolecular assemblies

2015;30:67-79.doi:10.1159/000435933

FIGURE 2 3.3 Isobolographic analysis confirms pharmacological synergy Isobolographic assessment demonstrated that the experimental ED 50 of the combination fell well below the theoretical additive line (Figure 3A)

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However, severe or persistent nausea and vomiting require medical attention