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The iron chelator DFO has been shown to decrease ROS production, mitigate hemoglobin-induced neurotoxicity, reduce brain edema, and enhance functional outcomes in both in vivo and in vitro models of CH (Regan and Panter, 1996

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These genes encode proteins of the angiopoietin-like family that not only inhibit LPL but also inhibit endothelial lipase (encoded by the LIPG gene)

Promising aldose reductase inhibitors (ARIs) (sorbinil, tolrestat, and zopolrestat) showed valuable results in animal models [157]