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Because of their role in the survival or differentiation of developing neurons and the recent discovery of their importance in regulating synaptic plasticity during adulthood, neurotrophic factors have been suggested as essential contributors to the etiology of neurodegenerative disorders (Schueller et al., 2020

Highlights The FOXO4-p53 axis drives senescence-linked neuroinflammation in brain aging

Under cover of darkness, the VC withdrew from the battlefield, winning their first major victory

This restores programmed cell death in cancer cell lines including SH-SY5Y neuroblastoma and U937 histiocytic lymphoma at 1-10 nanomolar concentrations, while paradoxically stimulating healthy NIH-3T3 fibroblast growth

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