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Aspirin appears to have both chemopreventive and chemotherapeutic effects (Chan et al, 2009

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TNF- is a crucial cytokine implicated in bone destruction and osteoclast formation in RA, along with IL-1, IL-6, and IL-17, which are highly expressed in RA patients

These findings suggest that L-citrulline intake may be associated with improvements in vascular endothelial function and subjective symptoms associated with impaired vascular function, such as shoulder stiffness and lower back pain, in healthy middle-aged and older adults with high-normal blood pressure

Arne Holmgren (19402020), who sadly passed away during the preparation of the first version of this manuscript