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Impairment of methyl cycle affects mitochondrial methyl availability and glutathione level in Downs syndrome

Korbonits M, Chitnis MM, Gueorguiev M, Norman D, Rosenfelder N, Suliman M, Jones TH, Noonan K, Fabbri A, Besser GM, Burrin JM, Grossman AB

The tyloxapol model reproduces a pathophysiological state characterised by impaired lipid clearance due to LPL inhibition and consequent hepatic lipid overproduction (lipogenesis), a combination that underlies dyslipidaemia and non-alcoholic fatty liver disease (Reference Packard, Boren and Taskinen4Reference Tocto-Chaquila, Tarrillo-Peralta and Vega-Huamn7)

Created by medical experts Tested to the highest standard GMP Certified Made in the USA This statement has not been evaluated by the Food and Drug Administration

doi: 10.3390/ijms222312736 [DOI] [PMC free article] [PubMed] [Google Scholar] 29