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moreover, miglustat acts as a chaperone for glucocerebrosidase (GBA1), 714 an enzyme whose loss-of-function variants are linked to both Gaucher disease and PD risk

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Moreover, CB-839 has been demonstrated to inhibit myeloma cell proliferation and enhance sensitivity to histone deacetylase (HDAC) inhibitors, suggesting that CB-839 has potential as a therapeutic agent for patients with MM [141]

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