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PMID: 189333

Meanwhile, the challenges in generating non-NF1 pLGG models include the low proliferation capacity and the specific permissive tumor microenvironment necessary for glioma formation ( NF1 heterozygous cells along with multiple different types of cells in the microenvironment to grow (77, 8791, 93), whereas NF1 and non-NF1-pLGG xenografts needed loss of specific T-cell population to form (68)

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In response to this stimulation, neutrophil DNA is released into the extracellular space and facilitates the formation of extracellular traps known as NETs, which serve to immobilize and eradicate pathogens

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