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73 In another case report, a 64-year-old man presented with acute respiratory distress syndrome due to COVID-19 severe pneumonia and secondary bacterial lung infection was admitted to Taihe Hospital in Shiyan, China and was given repeated bedside bronchoscopy at intervals of 1 day or 2 days with a large dose of 10,00015,000 mg/time of N-acetylcysteine nebulized inhalation solution lavage combined with routine nebulization and sputum suction airway management

CDK4/6 inhibitors are small molecules characterised by pyrido [2,3-d] pyrimidine-7-one or 4-(pyrazole-4-yl)-pyrimidine scaffolds, with modifications designed to enhance selectivity for CDK4 and CDK6 over other kinases

the most common are 677T, 1298C, or a combination of both