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So regular b12 has helped

Redistribution of macrophage cholesteryl ester hydrolase from cytoplasm to lipid droplets upon lipid loading

Vitamin B12 metabolism: a network of multi-protein mediated processes

people at higher risk of deficiency include older adults, those with gastrointestinal issues that impair absorption, people whove had gastric surgery, long-term strict vegans who do not supplement, and those on certain acid-reducing medicines
Peptides are getting a lot of attention right now, and the discussions around them are evolving