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It has indeed been demonstrated that p300/CBP transcriptional co-activator proteins (two central players in coordinating and integrating multiple signal dependent events with the transcription apparatus [215, 216]) bind to NRF2 in response to OS induced by arsenite and acetylate several Lys residues within the Neh1, the DNA binding region of NRF2, stabilizing it, increasing protein abundance, and promoting NRF2 nuclear localization [146, 214, 217] (Fig

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243,244 It is worth mentioning that He Zhu et als directional annealing casting (DAC) technique transformed the polyvinyl alcohol (PVA) hydrogel from a disordered porous structure into a highly oriented fibrous structure