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The effects of circadian rhythms on tissue homeostasis may be mediated through the modulation of metabolic homeostasis, neuroendocrine signaling, immune responses, oxidative stress, tissue repair mechanisms, and autophagy activity (Figure 2)

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A published study reported that sauna and nutritional therapy helped law enforcement officers exposed to methamphetamine during raids experience relief from persistent chemical-related symptoms

Such a candidate treatment may constitute part of an LPS reduction therapy that could provide evidence to support related theories such as the endotoxin theory of AD (Brown and Heneka, 2024)