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This pseudo-allergic response creates flushing, itching, or hives that mimic allergies but don't involve IgE antibodies

This is attributed to the heightened levels of NNMT potentially rendering NAM irretrievable, thereby constraining NAD + -dependent processes (Trammell and Brenner, 2015)

The prophylactic use of vitamin B12 was regarded as necessary for people diagnosed with atrophic gastritis, those with previous bariatric surgery, people at risk of B12 deficiency due to illnesses or medications, people with low or no consumption of animal source foods, and people ever diagnosed with vitamin B12 deficiency when they decided to become pregnant (Table 2)
