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Abstract Ferroptosis is a form of programmed cell death characterized by intracellular iron accumulation and lipid peroxidation, and earlier studies identified glutathione peroxidase 4 (GPX4) as an essential regulator of this process

Meanwhile, in contrast to the native -MC, mono-PEGylated -MC also remained at least 50% of antitumor activity against these three tumor cells at a concentration of 0.5 mg/mL for 72 h

14 (1), 8996 (2017) Snezhkina, A.V., Kudryavtseva, A.V., Kardymon, O.L., Savvateeva, M.V., Melnikova, N.V., Krasnov, G.S., et al.: ROS generation and antioxidant defense systems in normal and malignant cells

Glutathione works better when it has partners

Neither route requires enzymatic conversion before systemic uptake, which is why both bypass the first-pass metabolism that destroys oral glutathione in the gut and liver