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Sequence design of NADs Typically, NADs are designed and screened based on the pathogenic genes of specific diseases

Methylation of a CpG site near the ALDH1A2 gene is associated with loss of control over drinking and related phenotypes

Mitochondria-targeted molecules MitoQ and SS31 reduce mutant huntingtin-induced mitochondrial toxicity and synaptic damage in Huntingtons disease

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In addition, the number of G1-phase cells significantly increased after si-IGF-1R transfection, but the number of cells in the S and G2 phases noticeably decreased (Figures 6E,F