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In order to assess the study level risk of bias, we used the modified Cochrane risk of bias tool [22], and we evaluated the certainty of the evidence using the GRADE [20]

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However, under extreme acidic or alkaline conditions, it may undergo decomposition or other chemical reactions

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Animal models could be of help in better understanding the molecular basis of MVP, possibly providing sufficient information to tackle specific mechanisms aimed at slowing down MVP progression, therefore developing non-surgical therapies impacting on the natural history of this condition

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In mice, LRP1 deficiency causes glucose intolerance in the brain and hyperglycemia was observed to suppress LRP1 expression, finally causing insulin resistance and glucose intolerance [73]

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