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Despite claims that this implant is safer than its predecessor, the same types of ocular complications, including the need for explantation, were reported (Figure 1b,c) (El Chehab et al., 2020

Meanwhile, MR can also downregulate genes involved in an inflammatory response and immune cell infiltration, such as chemokine receptor (CCRs), chemokine ligand 7 (CCL7), IL-1, IL-6, IFN-, and TNF-

It has decades of randomized controlled trial data behind it and is widely regarded as the reference-standard topical retinoid against which newer molecules are measured

Neurol Neurochir Pol 44(1):6579 Claire VC, Larrive B (2017) Tumor angiogenesis and vascular normalization: alternative therapeutic targets

First the skin dies so becomes black