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Genetic damage in Parkin, PTEN Induced Kinase 1 (PINK1) genes and in the DJ-1 protein (which acts as a neuroprotective redox sensor) result in decreased activity of mitochondrial complex I enzyme and decreased adenosine triphosphate (ATP) production (Greco et al., 2023

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19 Phosphorylated Met (pMet) directly recruits adapter proteins such as Gab1, Grb2, and Src, which transmit the signal to two major downstream pathways of Akt and ERK (extracellular-regulated kinase)