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In a clinical trial, pure genistein supplementation (54 mg/day, P.O for one year) improved both cardiac function and left atrial remodeling in postmenopausal women with metabolic syndrome [138]

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The side chain of I243, the H and methyl group of T274, and the aliphatic region of the K242 side chain make van der Waals contact with the thione S of ET and all appear to meet the definition of a C-HS hydrogen bond 44 (Supplementary Table 2, Supplementary Fig